Click chemistry is a revolutionary way to make molecules: Best ideas of the century

Chemistry can be a messy, sluggish business, frequently involving cocktails of chemicals in round-bottomed flasks that must later be painstakingly separated. But in 2001, K. Barry Sharpless and his colleagues outlined an idea they called click chemistry that broke the mould. The snappy name, which was Sharpless’s wife Janet Dueser’s idea, summed it up well: a new set…

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