Grey’s Anatomy has been on the air for more than 20 years, so it makes sense that a lot of big Hollywood names have popped up for guest slots over the last 22 seasons.
Established actors like Christina Ricci and Sarah Paulson have graced the halls of Seattle Grace hospital, as well as some young actors who went on to have big careers: Millie Bobby Brown and Abigail Breslin, to name a few.
