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There’s a big change at the top of the CNBC Disruptor 50 with Anthropic rising to No. 1 in 2026.

Companies across the economy raced to embrace AI over the past year rather than risk being left behind by it, and that’s put the generative AI enterprise leader on the verge of surpassing OpenAI in valuation and above its rival on our annual list.

The domination of AI as a theme has not changed, but it has intensified and it is increasingly being reflected in the top-heavy nature of the Disruptor 50. Forty-three of the 50 companies in the 2026 list class say AI is essential to their disruptive business models. Total funding across the 2026 Disruptors rose to $337 billion, up from $127 billion in 2025 — an increase of more than 2.5x. Total implied valuation, skewed by the massive sums being raised by the top AI firms, climbed to $2.4 trillion from $798 billion, roughly tripling year over year.

In the new AI era, with the technology critical to so many business models, Silicon Valley dominates on the Disruptor map. Fourteen companies on this year’s list are based in San Francisco, with 18 in the Bay Area, and nearly half overall (23) based in California. That includes all but one of the top five companies, with the exception of Ramp.

But there are new companies (22 in all) and new themes, led by rapid successes in vibe coding and prediction markets. A major European AI player also makes its first appearance. And in 2026, AI continues its infrastructure-level remaking of the U.S., from the Hollywood movie to the military, from the American farm to the law firm.